OncoCurate: Automating Cancer Genomics Biocuration

 

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Click here for the paper

Click here for a research presentation

Click here for a video description

OncoCurate is a cloud application that automates the process of cancer genomics biocuration. There’s three main things the system does:

  1. Isolates Research Abstracts that Relate to Cancer Genomics (I made a novel algorithm to do this by writing a search engine that uses the “Hallmarks of Cancer” to identify research abstracts that are relevant to curation)
  2. Predicts Whether Unknown Mutations are cancerous just by “reading” the relevant articles (Let’s say you didn’t know KRAS was oncogenic but there was a lot of research published about it recently; OncoCurate will find that research and then use LSTMs to figure out whether KRAS is oncogenic or not; this saves human curators A LOT of time)
  3. Improves its own performance by responding to human feedback (Human biocurators can annotate OncoCurate’s results and that feedback is used to improve all aspects of the algorithm)

 

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